This is the page for most, if not all, characters in Grand Theft Auto: Wanted, regardless of their roles.
- Main article: Alex Russo
Alex Russo is the protagonist of the game and is fully customizable by the player in-game. Canonically, Alex Russo is a white male.
- Main article: Marcus Simmons
Marcus Simmons is one of the main antagonists in the game, representing the gangs' hostility towards Russo.
Gerald Winston, or simply known as Winston, is a minor character, appearing only in the beginning part of the game. He accompanies Russo on a covert op to take down Simmons, but is killed. Winston's death is used as leverage in the framing of Russo.
Erick Chung, or simply known as Chung, is a minor character, appearing only in the beginning part of the game. He accompanies Russo on a covert op to take down Simmons, but is killed. Chung's death is used as leverage in the framing of Russo.
Franklin Clinton returns from his debut appearance in Grand Theft Auto V as a minor main character in the story. He is one of Russo's friends throughout the entire game and helps the Protagonist throughout as well.
- Although Anywhere City was based off the 3D universe variant of Liberty City (which is based off New York City) in Grand Theft Auto II, it is based off Chicago, Illinois, USA in Wanted.